Acute M3, also known as acute promyelocytic leukemia, is characterized by bleeding symptoms, including bleeding gums, petechiae and petechiae on the mucous membranes of the skin, and increased menstruation in female patients. Other types of leukemia also have bleeding, but M3 bleeding is more pronounced, showing not only bleeding but also clotting abnormalities, often in the form of large bruises and petechiae on the skin. Differentiation relies mainly on bone marrow examination, mainly proliferation of promyelocytes, and the diagnosis can be clarified by bone marrow morphology, flow and chromosome tests. If leukemia has been identified, combined with abnormal coagulation, high vigilance is required for M3, but it is difficult to make a differential diagnosis from other diseases in terms of symptoms.