For wasting diabetic patients, the general choice of drugs is more recommended to promote insulin secretion, because insulin, as the only synthetic hormone inside the body, can convert blood sugar into fat and protein, which is conducive to weight gain of wasting patients. Therefore, oral medications are mainly sulfonylurea pro-secretors, including glimepiride, glipizide, glipizide and gliclazide, while drugs such as Repaglinide and nateglinide can also be recommended, as they can promote insulin secretion. In addition to oral hypoglycemic drugs, there is another class of drugs that is more recommended, which is insulin, because insulin can act directly on the body to convert excess sugar into fat and protein, which can promote weight recovery within the shortest time, and is very crucial for the improvement of patients’ symptoms and nutrition.