If a hepatitis B carrier has abnormal liver function and high HBV-DNA, he is too contagious to get pregnant and must be treated in time. Even after the hepatitis B carrier’s condition has stabilized, it is important to do a good job of blocking the hepatitis B virus from mother to child if you become pregnant. Blockage of transmission during delivery: HBIG injection immediately after birth The timing of the injection is critical and should be given immediately after birth, the sooner the better, especially if the virus in the mother’s blood is large. Mother-to-child transmission is one of the important modes of transmission of HBV and includes four main routes (see table below). Currently, giving newborns hepatitis B immunoglobulin (HBIG) + hepatitis B vaccine is a better way to interrupt mother-to-child transmission. The common method is to inject 100-200 IU of HBIG into one deltoid muscle and 10 μg of hepatitis B vaccine into the other deltoid muscle after birth, followed by 10 μg of hepatitis B vaccine each at 1 and 6 months. Because the hepatitis B virus enters the newborn mainly during delivery, if HBIG is injected immediately after birth, the HBIG can neutralize the virus as soon as it enters the body. If the injection is late, the virus will have already entered the liver of the newborn and HBIG will no longer be able to work. Therefore, the timing of HBIG injection is critical and should be given immediately after birth, the sooner the better, especially if the virus in the mother’s blood is large. The reference to prescribing injection within 24 h is not appropriate. Blockage of intrauterine transmission: application of antiviral drugs is more effective The effectiveness of HBIG injection in mothers for the prevention of mother-to-child transmission of HBV is inconclusive and therefore not recommended. For chronic HBV carriers, antiviral drugs are more effective, but their application should be determined by the level of HBV DNA in their blood and the patient’s wishes.