Splenomegaly is one of the more common diseases in clinical practice. Generally, different treatment plans can be chosen according to the severity of splenomegaly and the different physical conditions of the patients. If the degree of splenomegaly is mild and does not cause the destruction of blood cells and symptoms of gastrointestinal bleeding, close observation and regular review of ultrasound or CT are recommended, and no special treatment is needed. In order to avoid complications such as hemorrhagic shock and hepatic coma due to excessive blood loss, it is recommended to surgically remove the huge spleen and sever the cardia vessels to avoid the destruction of blood cells and symptoms of gastrointestinal bleeding. Third, in elderly people with a large spleen, the body condition is poor and cannot tolerate surgery, so the splenic artery can be embolized through interventional therapy to reduce the size of the spleen due to ischemia and hypoxia, thus achieving a certain therapeutic effect.