What are the materials used for cranial bone repair? The skull is not only a protective layer for the soft tissues of the brain, but also an important guarantee for maintaining the aesthetics of the head. But life is often full of accidents, maybe an inadvertent collision will make our skull lose a piece of bone. If not repaired in time, not only the normal functional environment of the brain is not guaranteed, but also it will cause a great burden to the patient psychologically. What is the best material to choose for skull repair? Material is the most important thing in skull repair surgery. A good material can not only improve the success rate of the surgery. And it can reduce the chance of post-operative complications. Thousands of years ago, doctors tried to use various materials for skull repair, but there were no suitable materials for doctors to choose due to the backward medical knowledge and technical means at that time. With the advancement of medicine, more and more cranial repair materials have become available for use. Plexiglass, light apatite and calcium phosphate bone cement materials, which were once used in clinical practice, were gradually withdrawn from the medical arena due to their poor clinical results. The commonly used material for cranial repair today is titanium mesh, which is also a quality material with long-lasting application and good results. However, the metallic properties of titanium mesh often have consequences for patients such as sensitivity to cold and heat reactions and CT image errors. Thanks to the efforts of medical researchers, a new type of cranial repair material has been applied clinically above the PEEK material used by hospitals. The material is known as polyether ether ketone, a polymer biomaterial that is extremely close to human cranial bone in terms of elasticity, heat transfer, stiffness, and stability. Numerous clinical cases have shown that there are no discomfort or complications associated with PEEK cranial repair materials, so PEEK is undoubtedly the premium choice for cranial bone repair today.