There are more causes of hypoglycemia, drug factors, pancreatic β-cell hyperplasia or pancreatic β-cell tumor, autoimmune factors and long-term malnutrition can lead to hypoglycemia, and the hypoglycemic state can easily lead to acute adverse events in human body, which can lead to coma or even death. Common causes 1, drug factors: patients with diabetes are prone to induce hypoglycemia during the use of hypoglycemic drugs, especially sulfonylureas or programs containing insulin, which can easily lead to hypoglycemia. Sulfonylureas can promote insulin secretion, leading to hyperinsulinemia in the body. And exogenous insulin is not as flexible as endogenous insulin when applied, so it can easily lead to hypoglycemia; 2. Islet beta-cell hyperplasia or islet beta-cell tumor: it leads to inappropriate release of insulin in human body, which in turn leads to elevated insulin level, and usually prone to hypoglycemia in fasting state; 3. Autoimmune factors: it can also lead to inappropriate release of insulin within a short period of time, which induce hypoglycemia; 4. Gastrointestinal surgery: due to the change of gastrointestinal anatomy, it is easy to lead to hypoglycemia after meals; 5. Long-term malnutrition: inadequate intake, decreased physical fitness and insufficient energy supply can also lead to hypoglycemia, for example, long-term consumption of tumor can easily lead to hypoglycemia in human body. Hazardous hypoglycemic state can easily lead to acute adverse events in the human body. When hypoglycemia is easy to induce the occurrence of cardiovascular and cerebrovascular accidents such as heart attack and cerebral infarction, and it is easy to lead to insufficient energy supply of brain cells, and the metabolism of brain cells completely depends on glucose to supply energy, which can lead to brain dysfunction. If there is hypoglycemia for more than six hours, it will lead to hypoglycemic encephalopathy in human body, and the patient will be in coma and even easy to induce death. Therefore, we must pay attention to hypoglycemia, and people who usually use hypoglycemic drugs should strengthen the monitoring of blood sugar and adjust the dosage of drugs in time. If a patient has repeated fasting hypoglycemia, it is necessary to know the insulin level and whether there is a possibility of inappropriate use of insulin. After the occurrence of hypoglycemia, it should be corrected by eating sugary food in time, and if there is already a consciousness disorder, it should be sent to hospital urgently for treatment.