There is no most effective way to prevent motion sickness 30 minutes before the ride oral anticholinergic drugs, such as Benadryl. Motion sickness is mainly caused by vestibular dysfunction, to prevent motion sickness can be life care, oral medication and so on. 1. Life care: take a full rest one day before the car, get on the car and choose the position in front or by the window, don’t look at the phone in the car, don’t read books, try to rest, keep your head immobile, conditions allow you to lie down and close your eyes to rest. 2. Drugs: more severe motion sickness, half an hour before the car can eat some motion sickness drugs, such as Benadryl and other anticholinergic drugs; can also be in advance in the navel on the motion sickness stickers and so on. The medication should be directed by a doctor. If the motion sickness is more serious, it is recommended to go to the regular hospital for a detailed examination, and follow the doctor’s instructions to do the relevant training.