Intolerable shoulder pain may be related to factors such as frozen shoulder, tenosynovitis of the long head of the biceps, cervical spondylosis, etc. Medications can be used according to the cause. 1. Frozen shoulder: it is usually the result of synovitis and joint capsule fibrosis, which may cause intolerable shoulder pain. It is recommended to take oral medication such as Meloxicam tablets and ibuprofen under doctor’s guidance. 2. Biceps tenosynovitis: generally acute trauma, chronic strain, etc., leading to the biceps tendon sheath of the long head of the biceps tendon with congestion, adhesion, inflammation and other conditions. Shoulder pain intolerable phenomenon, can be under the guidance of the doctor oral aspirin, celecoxib capsules and other drugs treatment. 3. Cervical spondylosis: when the cervical spondylosis nerve is compressed, the symptoms of intolerable localized pain in the shoulder may occur, accompanied by pain in the back of the neck, stiffness, numbness and weakness of the limbs and other symptoms. It is recommended to take oral medication such as methylcobalamin tablets and eperisone hydrochloride tablets under the guidance of a doctor. Shoulder pain is intolerable, should go to the hospital in time to clarify the cause of the disease, under the guidance of the doctor targeted treatment.