Cholesterol is also divided into good and bad: HDL-C is the “good” cholesterol, which has a protective effect on cardiovascular, while LDL-C is the “bad” cholesterol, which is the culprit of cardiovascular diseases. They will drill into the arteries under the endothelium, forming atherosclerotic plaques, promoting thrombosis and ultimately leading to cardiovascular disease Capital Medical University Xuanwu Hospital Health Screening Center Zhao Jing LDL too much, piled up in the artery wall, forming “plaque”. As cholesterol accumulates, the plaque thickens, blocking the blood vessels and impeding blood flow, leading to lack of oxygen. Plaque can appear anywhere in the body and cause different diseases.