Kidney cancer with bone metastasis for three years can be treated by radiotherapy, targeted therapy and immunotherapy, or bisphosphonates can be used to relieve symptoms, or palliative surgery can be adopted. In addition, some kidney cancers can be treated with chemotherapy. 1. Extracorporeal radiotherapy: taking extracorporeal radiotherapy is a traditional treatment means, which has certain pain-relieving effect and can prevent patients from having more serious conditions, such as paraplegia. 2. Targeted therapy and immunotherapy: at present, FDA has approved anti-VEGF/VEGFR pathway (sorafenib, etc.), inhibition of mTOR pathway (everolimus, etc.), and immune checkpoint inhibitor (nabumab, etc.) for the treatment of metastatic renal cancer. 3. Bisphosphonates to relieve symptoms: bisphosphonates are used to slow down the continued destruction of bones by cancer cells and reduce the occurrence of bone events, which can improve the quality of life of patients and is a more important supportive treatment at present. 4. Surgery: for cases of nerve compression or pathological fracture, surgery can relieve nerve compression, prolong the patient’s life and relieve symptoms. Surgical methods include minimally invasive and vertebroplasty. 5. Chemotherapy: for some kidney cancers, cisplatin and gemcitabine can be used for chemotherapy. Patients with bone metastasis of kidney cancer should have regular review before cooperating with doctors for treatment period to control the development of the disease. All the above medications should be used under the guidance of doctors, avoid self-medication.