Drinking alcohol 12 hours after taking cephalosporin may cause disulfiram-like reaction, which is manifested as shortness of breath, palpitations (rapid heartbeat, often accompanied by panic), flushing, chest tightness, and some of them may have lowered blood pressure, shock, accompanied by nausea and vomiting. Disulfiram-like reaction is mainly due to the use of cephalosporin and then drink alcohol, will lead to acetaldehyde poisoning in the body, most of the clinical manifestations appeared within half an hour after drinking alcohol, disulfiram-like reaction in the period of drug use, and discontinuation of the drug within 7 days may occur. Therefore, after the use of cephalosporin, during the period of use and within 7 to 10 days after discontinuation of the drug, it is best not to drink alcohol, or intake of food, drinks containing alcohol, in addition to drinking alcohol within 72 hours, do not use cephalosporin drugs, if the use of cephalosporin drugs after drinking alcohol, it should be closely observed, and the emergence of abnormalities in a timely manner to consult a doctor, follow the doctor’s instructions for treatment. Drugs should be used in accordance with medical advice.