Indeterminate presentation syndrome is a disease with a group of indeterminate physical symptoms such as headache, palpitation, insomnia, gastrointestinal dysfunction, lethargy, easy fatigue, and lack of corresponding organic lesions. In the past, patients with this disease were transferred to various departments for treatment, and the names of the disease kept increasing while the treatment was often ineffective, and even aggravated the disease medically. In recent years, the Department of Pain Management has applied a comprehensive treatment method based on stellate ganglion block, supplemented by psychotherapy, to treat this disease, and obtained remarkable results. I. Etiology Psychosomatic factors such as overload of life events, dysregulation of the body to environmental conditions, etc.; endocrine dysfunction such as ovarian hypofunction, post-ovarian resection, etc. can also be causative factors. These causes lead to a variety of clinical manifestations of patients with mainly dysfunctional vegetative nerves, especially increased sympathetic nervousness. II. Clinical features The disease is mostly seen in menopausal and young women. The patient’s statements are extremely broad. Systemic statements include tiredness, fatigue, fever and night sweats, accounting for about 18%; neuromuscular statements include insomnia, dizziness, numbness, headache, stiffness of shoulder muscles, back pain, lumbago and weakness of lower limbs, accounting for about 36.3%; cardiovascular statements include palpitation, shortness of breath, chest tightness and swelling, accounting for about 22%. In addition, cold is also an important statement of the disease, mainly manifested as cold hands and feet, fear of cold environment, often prefer to use warmth or heating equipment, curled body sleep in winter, often prone to frostbite, etc.. In addition to the characteristics of many statements, the disease also has a temporal and spatial irregularity in the statements, such as the statement of pain in a certain area, but suddenly shifted to another unrelated area of pain or other discomfort. The aggravation of these symptoms is related to psychological and social factors, yet there is no corresponding organic lesion found during the examination. III. Diagnostic basis 1. There are many statements that show spatial irregularity in time. Among them, chills are particularly important for the diagnosis of this disease. The diagnosis of chills, in addition to conscious symptoms, a positive Shellong rise test has clinical value in confirming the diagnosis of the disease. The so-called Shellong test means that after lying quietly for 15-30 minutes, the systolic blood pressure, diastolic blood pressure, heart rate, beat-to-beat output, cardiac index and peripheral circulatory impedance are measured respectively, and then the above indicators are measured again after 10 minutes in a movable standing position, and if there is no significant change in diastolic blood pressure and heart rate, but all other indicators have significantly decreased, the test is positive. 2. It occurs in menopausal and young women, and there may be psychological, social and endocrine factors in the history, and the psychological test may be inclined to somatization and hypochondriasis. 3. Indeterminate statements (symptoms) and signs do not match, and there is no positive development in various auxiliary examinations. IV. Treatment 1. General treatment: Regular life, appropriate participation in cultural and sports activities. Adapt or avoid bad living environment, maintain good mental state. 2, drug treatment can be given vitamin B vitamin E and placebo, beta-blocker insulin and other sympathetic nerve inhibitors can also be used. 3, stellate nerve block 1% lidocaine 8 ~ 8mL, both sides of the stellate ganglion alternate block, every 1 ~ 3 days block, usually 1 ~ 2 times there is a significant effect, 20 ~ 30 times can be expected to heal. The efficacy of the block can be judged according to the changes in appetite, sleep, vertigo, constipation, blood pressure, menstruation, cold, and postural regulation disorder items. The mechanism of stellate ganglion block for the treatment of this disease is mainly to release the excessive tension of sympathetic nervous system and regulate the disordered plant nervous function. 4, other especially should pay attention to psychotherapy, other such as branch river therapy, acupuncture and TENS, Chinese medicine’s can be used for the treatment of this disease. Among the above methods, the effect of stellate nerve block is the most accurate, but if it can be combined with other therapies for comprehensive treatment, the effect is better.