Immunoglobulin (immunoglobulin) refers to animal proteins with antibody activity. It is mainly found in blood plasma, but also in other body fluids, tissues and some secretory fluids. The normal range of serum immunoglobulin (Ig) includes: IgG, IgA, IgM, IgD, IgE. its normal range: IgG 7,6~16,6g/L; IgA 0,71~3,35g/L; IgM 0,48~2,12g/L; IgD 0,01~0,04g/L; IgE 0,001~0,009g/L. Then, the diseases that cause patients’ serum What are the diseases that can elevate immunoglobulin? The following is a brief introduction: 1. Autoimmune diseases: autoimmune diseases are diseases caused by the body’s immune response to its own antigens, resulting in damage to its own tissues. Many diseases are successively classified as autoimmune diseases. It is worth proposing that the existence of autoantibodies and autoimmune diseases are not two equivalent concepts. Autoantibodies can exist in normal people without autoimmune diseases, especially in the elderly, such as anti-thyroglobulin antibodies, thyroid epithelial cell antibodies, gastric wall cell antibodies, cell nuclear DNA antibodies, etc. Sometimes, damaged or antigenically altered tissues can stimulate the production of autoantibodies, for example, in myocardial ischemia, necrotic myocardium can lead to the formation of anti-myocardial autoantibodies, but this antibody has no pathogenic effect and is a secondary immune response. 2, tuberculosis: tuberculosis is commonly known as “consumption”, which is a highly contagious chronic wasting disease caused by the invasion of Mycobacterium tuberculosis into the human body. It is not affected by age, gender, race, occupation, region, many organs and systems of the body can suffer from tuberculosis, of which pulmonary tuberculosis is the most common. More than 90% of TB infection is transmitted through the respiratory tract. TB patients are infected through coughing, sneezing, and loud noises that cause droplets with Mycobacterium tuberculosis to be sprayed out of the body and inhaled by healthy people. The typical manifestations are: cough, sputum, hemoptysis, chest pain, and difficulty in breathing. It is a chronic infectious disease with a long history of harming human health and has spread worldwide, causing millions of deaths. China is now one of the 22 countries with a high burden of tuberculosis worldwide, with the second highest number of tuberculosis cases in the world, second only to India. The current number of existing infectious TB patients in China is estimated at 2 million. 3. Multiple myeloma: Myeloma (also known as plasmacytoma) is a malignant tumor originating from plasma cells in the bone marrow, and is a relatively common malignant tumor. It is a relatively common malignant tumor. There are single and multiple tumors, and the latter is more common. Multiple myeloma, also known as myeloma (MM), is caused by the malignant transformation of plasma cells that synthesize and secrete immunoglobulins, and the proliferation of a large number of monoclonal malignant plasma cells causes easy involvement of soft tissues, and may have extensive metastasis in the late stage, but rarely pulmonary metastasis. It is more commonly seen in the spine, accounting for 10% of the primary tumors of the spine, and is more common in the lumbar spine. The age of prevalence is more than 40 years old and the ratio of male to female is about 2:1. It mostly occurs in men over 40 years old, and the prevalent sites are spine, rib, skull and sternum in order.