Stay up all night eye pain can not open the eyes, generally eye fatigue caused by excessive eye use, can follow the doctor’s instructions to use artificial tears class eye drops treatment, relieve eye discomfort, but ofloxacin eye drops can not treat eye fatigue, so it is not recommended to use. Stay up late patients appear eye pain, can not open the eyes, generally long-term eye fatigue caused by visual fatigue, patients can follow the doctor’s instructions to use artificial tears class eye drops to relieve eye discomfort, such as sodium vitrate eye drops, polyethylene eye drops and so on. Ofloxacin eye drops belong to antibiotic drugs, can not treat eye fatigue, so it is not recommended to use. Patients can experience transient eye burning, eye pain, photophobia and other adverse reactions after using of ofloxacin eye drops. It is not recommended for pregnant women as well as lactating women, and is contraindicated in case of allergy to ofloxacin or quinolones. It is recommended that patients with ocular discomfort seek timely medical attention to assess their condition and follow the doctor’s instructions for treatment, do not use medication without authorization to avoid causing adverse reactions.