Beau’s line generally refers to the transverse nail groove. Nails with horizontal grooves may be caused by infection, hypothyroidism, iron deficiency anemia, etc. Infection can be treated with mupirocin cream, while hypothyroidism and iron deficiency anemia need to be treated first. 1. Infection caused by: such as bacterial infections can cause nail Beau’s line, you can use mupirocin cream treatment for skin infections caused by gram-positive cocci, mupirocin or other ointment containing polyethylene glycol allergy is contraindicated, the product is generally no adverse reactions, and occasional local burning sensation of stinging sensation and itching and other symptoms. 2. Hypothyroidism: it is caused by the reduction of thyroid hormone synthesis and secretion, which will lead to nails with Beau’s line, and need to actively treat the primary disease, such as oral levothyroxine sodium tablets. 3. Iron deficiency anemia: due to an imbalance between the body’s demand for iron and the supply of iron, resulting in the depletion of the body’s iron stores, there is a lack of iron in the red blood cells and anemia, which can lead to nails with Brödermann’s lines. Need to actively treat the primary disease, such as oral ferrous gluconate. Nails with Beaufort’s lines may also be related to malnutrition, heart attack, etc. It is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy. Medications should be used as prescribed by the doctor.