In the current life, the number of people with cranial defects is gradually increasing, mainly due to some external emergencies and intracranial lesions in the postoperative sequelae, for many patients, cranial defects are unfortunate, because without the protection of an important barrier on the surface layer of the brain, people’s health and safety are always at risk in all aspects. This is why it is important to undergo cranioplasty as soon as possible. Cranioplasty is a routine neurosurgical procedure that has been developed over many years and is well established. However, there are still many patients who suffer from postoperative problems such as infection, abrasion of the skin, and postoperative aesthetics, mainly due to the different types of surgery chosen. For example, the titanium mesh cranial bone repair currently used in the clinic may have the disadvantages of rejection and infection, material exposure, interference with the impact of the examination, etc., so the patients need to choose a more advanced and safer repair surgery when carrying out the repair. Our department introduced the new PEEK cranial bone repair surgery for patients to carry out cranial bone repair, and achieved good results, recognized and praised by patients and their families. It is reported that PEEK cranial bone repair is a more advanced kind of surgery at present, this surgery uses PEEK as the implant material of cranial bone repair, unique embedded repair method, material thickness, hole diameter, groove to do the unique design, high comfort, low rate of postoperative rejection and infection, and it does not affect the postoperative MRI and CT examination. At the same time, in order to improve the aesthetics of the appearance, the surgical design introduces the concept of plastic surgery, and during the operation, the added plastic elements are further improved and refined, such as subcutaneous freeing, skin flap transfer, myotendinous flap transfer, eyebrow arch shaping, etc., to ensure the symmetry of both sides of the head and the aesthetics of the appearance of a natural shape after the operation.