After the combined resection of liver metastasis of colon cancer should follow the doctor’s prescription of medication, capecitabine should not be taken for a long time to avoid adverse effects on the body. Capecitabine is an adjuvant chemotherapeutic drug for colon cancer, which is used in Dukes’ C stage, after radical surgery of primary tumor. For patients with colon cancer liver metastasis combined with post resection, the drug should be taken under the guidance of the doctor, and should not be used on its own or change the amount of drug regimen. The use of capecitabine needs to be carried out according to the doctor’s prescription, usually a single course of treatment in about three weeks, according to the condition of each person, the specific course of treatment is different, the recommended length of treatment is usually no more than 6 months. Capecitabine can not only inhibit the growth of tumor cells, but also affect the metabolic growth of normal cells, so long-term use of capecitabine has a greater impact on the human body, may cause anemia, edema, fever, nerve sensory abnormalities and other symptoms, and in severe cases may affect the function of the body’s organs. It is recommended to go to a regular hospital to assess the condition, use medication under the guidance of a doctor, and avoid abusing drugs.