Creatinine 400μmol/L more is more serious, patients need to pay attention in time. Usually creatinine 400μmol / L more, consider the blood creatinine value, and the normal value of blood creatinine for men 53 ~ 106μmol / L, women 44 ~ 97μmol / L, so creatinine 400μmoI / L more than the situation is more serious, the patient needs to pay attention to timely. Usually the patient blood creatinine 400μmoI / L more, consider the glomerular filtration function is reduced due to, mostly in acute and chronic renal failure. Acute renal failure can be seen in gastrointestinal bleeding, urinary tract obstruction, heart failure, diarrhea, drug damage, etc., can be prescribed to blood transfusion, relief of obstruction, improve cardiac function, rehydration, immunosuppression (prednisone acetate, cyclophosphamide) and other treatments, the general condition can be relieved, and even the blood creatinine back to normal. Chronic renal failure can be seen in hypertensive renal damage, chronic glomerulonephritis, diabetic nephropathy, etc., generally poor prognosis, incurable, the purpose of the treatment is to slow down the progress of the disease, the late stage of the disease may be developed into uremia, the need for renal replacement therapy. It is recommended that patients with blood creatinine test results of 400 μmoI/L should seek medical treatment at regular hospitals in time and follow the doctor’s instructions for systematic treatment after the cause of the disease is clarified.