According to epidemiological surveys, women have a significantly higher chance of developing gallstones than men, with a male to female ratio of 1.5 to 2:1. This is inextricably linked to women’s physiological characteristics and lifestyle habits, such as estrogen levels, pregnancy, and skipping breakfast. Under normal circumstances, estrogen in women’s body is maintained at a high level, especially in some young women because of contraception and beauty applications of large amounts of estrogen, which increases the level of estrogen in the body, increasing the chance of developing gallstones. Generally speaking, estrogen affects the formation of gallstones in the following ways: 1. uptake of cholesterol in plasma LDL, thus increasing the cholesterol saturation of gallbladder bile. 4, affect the emptying of the gallbladder, causing biliary sweat depression. Pregnancy 1. During pregnancy, the hormone level in the body will be greatly changed, and the biliary tract function will be easily disturbed, causing the smooth muscle contraction to be weak and bile retention in the gallbladder, coupled with the relative increase of cholesterol in the blood during pregnancy, precipitation will easily occur; 2. The increased viscosity of bile and the retention of bile in the gallbladder create conditions for the formation of gallbladder stones. 3, during pregnancy, in order to increase nutrition, pregnant women often consume more sugar, fatty foods, fat and cholesterol intake, easy to form cholesterol stones, too much sugar can promote insulin secretion, accelerating cholesterol deposition. The more the number of pregnancies, the higher the incidence. Third, do not eat breakfast In the inter-digestive period, bile flows into the gallbladder for storage, after eating, the gallbladder contracts, while the sphincter of Oddi diastolic, bile can be smoothly discharged into the duodenum to participate in digestive activities. Many women often do not eat breakfast due to work pressure and weight loss, so that the bile cannot be discharged to the intestine in time, it will be over-concentrated in the biliary system, and the concentration of cholesterol or bilirubin will rise, which will easily precipitate to form stones. Fourth, less activity Women are naturally quiet and not active, due to exercise and physical labor less, the contraction force of their gallbladder muscle is bound to decline over time, bile emptying delayed, easy to cause bile stagnation, cholesterol crystals precipitation, creating the conditions for the formation of gallstones.