Hepatitis B playing interferon low white blood cells, if only a slight decrease, you can use Diyu ascending white tablets and other leukocyte-boosting drugs, if the total number of white blood cells is less than 0.5 × 10^9 / L, you need to stop using interferon, change to other anti-hepatitis B virus drugs. Interferon is a broad-spectrum antiviral drug that does not directly kill or inhibit the virus, but mainly acts on cells through cell surface receptors to produce antiviral proteins that inhibit the replication of the hepatitis B virus. The main side effects of interferon include flu-like symptoms, bone marrow suppression, psychoneurological symptoms, etc., of which the bone marrow suppression effect will lead to a drop in white blood cells and platelets. Some can even cause a significant drop. When there is a mild decline in white blood cells, white blood cell boosting medications such as Diyu Lianbai Tablets and Licorice can be used to help white blood cells rise. But if there is a significant drop, as low as 0.5×10^9/L, you need to stop using interferon and switch to other anti-hepatitis B virus drugs for treatment. Drugs need to be used under the guidance of a professional physician, and should not be used arbitrarily on their own.