In general, try not to combine two antiviral drugs. Such as lamivudine combined with adefovir, or tebivudine combined with adefovir, the combination of the two will increase the occurrence of adverse reactions, such as low phosphorus, low calcium, osteoporosis, renal bone disease, impaired renal function, etc. The incidence of combined use is definitely higher than that of single use, and the current combination of the two is actually not completely reasonable. Do not use the combination until you have to. In fact, if the preferred medication is correct, drug resistance rarely occurs, the joint use is not necessary, so the preferred medication is very important, it is recommended to go to a regular hospital specialist.