Since the implanted prosthesis is a foreign body to the human body, there is a possibility of rejection. Serious rejection reaction is manifested as redness of the skin and exposure of the implant, at which time the implant must be removed surgically. With the replacement of implants and the deepening of plastic surgeons’ understanding of breast augmentation surgery, severe reactions are rare, and it is now believed that the individual’s rejection of the implant is the intrinsic determinant. In addition, fibrous contracture is the most common complication of breast implant augmentation, and contracture can be classified into four grades according to Baker’s grading; grade I/II is generally not treated with special treatment, and grade III/IV requires re-surgery. In some patients, periosteum contracture occurs when the implant is replaced several times. At this time, autologous tissue transplantation without rejection reaction is considered when re-operation is performed, and autologous fat injection for breast augmentation is commonly used. Autologous fat injection for breast augmentation has a long-lasting effect and is very safe, with a real breast shape after surgery. However, due to the limitations of the survival rate of fat transplantation and the patient’s own fat volume, it usually takes 1-3 times of surgery, with an interval of at least 2-3 months between the two surgeries.