There are various causes of inguinal lymph node enlargement, as follows: 1, local infection of the lower limbs: for example, there are wounds and breaks on the feet or legs; 2, organ lesions and inflammation: diseases of the organs of the genitourinary system should be treated with the corresponding organ lesions; 3, systemic diseases: for example, one of the manifestations of lymphoma should be treated with chemotherapy for lymphoma; 4, HIV infection: to target HIV virus infection itself for the corresponding antiviral treatment. In conclusion, there are various causes of inguinal lymph node enlargement, and various drugs for treatment.