The principles of treatment for constipation First of all, the cause must be identified and treated for the cause; laxatives should not be abused, and dietary therapy should be considered first for patients with constipation, i.e., eating a certain amount of fiber and water and developing physiological bowel habits. The application of laxatives should be based on the characteristics of each drug, the reasonable choice. At present, the clinically applied drugs for constipation are: volumetric laxatives, stimulant laxatives, lubricating laxatives, osmotic laxatives, prokinetic drugs and 5-HF-4 agonists. Volumetric laxatives and osmotic laxatives are recommended. 1.Volumetric laxatives Increase water content and solids play a role in increasing dietary fiber, increasing the volume of stool, accelerating intestinal transmission, and increasing the number of bowel movements. Such as febi bran, wheat bran, corn bran, konjac starch, methyl cellulose Agar psyllium preparation. Small side effects, can be taken for a long time. 2, stimulant laxatives fast-acting, potent, drugs or their metabolic products can produce stimulating effects on the intestinal wall, so that the intestinal motility increases. The main drugs in this category are: fruit guide, castor oil, rhubarb, senna, etc.. But note that such drugs because of the stimulation of intestinal mucosa and intestinal wall nerve plexus, and may cause muscle weakness of the large intestine, the formation of drug dependence, and therefore mainly for the need for rapid laxation, should not be long-term application. 3, lubricating laxatives milder laxative, its role is mainly to lubricate the intestinal wall, soften the stool, reduce water absorption, and promote intestinal peristalsis. Such as liquid paraffin glycerol corkage (also contains intestinal stimulants). The main drawback of these drugs is the poor taste, weak, long-term application will cause malabsorption of fat-soluble vitamins. 4, osmotic laxatives including non-absorbed sugars, salt laxatives and polyethylene glycol, Fosamax, Dulcol. Non-absorbed sugars can increase the volume of feces in the intestinal cavity and stimulate intestinal peristalsis. Salt preparations are incompletely absorbed in the intestine, allowing water to seep into the intestinal lumen. Polyethylene glycols are not absorbed and metabolized by the intestine after oral administration, and can effectively treat constipation. Such as lactulose glycerol sorbitol, etc. Especially suitable for the elderly, maternity, children and post-operative constipation. Diabetic patients use with caution. 5, enterokinetic drugs act on the endings of the intestinal nerve, release motor neurotransmitters, antagonize inhibitory neurotransmitters or act directly on smooth muscle, increase intestinal power, effective for slow transmission type constipation. For example, cisapride, tegaserod, etc. Tegaserod is effective for constipation type of irritable bowel syndrome, especially for patients who have already used osmotic laxatives and enteral fiber but still not effective. We suggest that you pay attention to drink more water and eat more food rich in crude fiber.