Hepatitis B surface antigen 20,000 + IU/ml, the need for anti-interferon, also need to be based on abnormal liver function to decide. If there is no damage to the liver generally do not need to play, liver function abnormalities need to play. 1. Normal liver function: this kind of situation proves that the patient belongs to hepatitis B virus carriers, generally do not need to receive treatment, only need to receive regular liver function tests. 2. Abnormal liver function: generally include elevated transaminases and bilirubin, indicating that the liver has been damaged, need to receive drug treatment, the current hepatitis B antiviral first-line drugs include entecavir and tenofovir. Interferon therapy may also be considered. The conditions for interferon injection: hepatitis B virus DNA level is less than 10^8; transaminase level is relatively high, 90-900U/L; hepatitis B surface antigen is less than 25,000IU/ml. Side effects of interferon injection, generally include fever, fatigue, dizziness, headache, as well as nausea, etc. It is contraindicated for patients with autoimmune chronic hepatitis. In addition, the application of interferon has certain risks, and it is recommended that patients need to be under the guidance of a specialist.