Valsartan and olmesartan are generally interchangeable, but it is not recommended to replace them arbitrarily. Valsartan and olmesartan both belong to the angiotensin II receptor antagonist class of antihypertensive drugs, the mechanism of action of the drugs is similar, and the indications are both used in the treatment of hypertension. In the treatment of hypertension, these two drugs are generally interchangeable. If one of the drugs is not effective in lowering blood pressure, you can try to switch to another antihypertensive drug, and pay attention to monitoring blood pressure during use. The main adverse reactions of both valsartan and olmesartan are headache, dizziness, nausea, abdominal pain, and occasional elevation of liver function indicators. The main contraindications of valsartan are those who are allergic to the drug, pregnant and lactating women. Contraindications to olmesartan are mainly hypersensitivity to olmesartan, contraindicated in pregnant women. The choice of antihypertensive drugs need to be carried out under the guidance of a professional physician, do not change drugs without authorization, to avoid adverse consequences.