The main difference between the 60ug hepatitis B vaccine and the 20ug hepatitis B vaccine is the dose. The dose of 60ug vaccine is large, the immunization effect is obvious after vaccination, but at the same time, the adverse reaction is more serious, the dose of 20ug vaccine is relatively small, the immunization effect is weaker than that of 60ug vaccine, and the adverse reaction is less serious. Usually, 20ug of hepatitis B vaccine is used for the first vaccination. Due to the uncertainty of the body’s tolerance, if the 20ug of hepatitis B vaccine can produce sufficient amount of protective antibodies, the body can avoid serious adverse reactions. If immunization with the 20ug dose of hepatitis B vaccine fails, a subsequent 60ug dose of hepatitis B vaccine can be administered, which usually achieves the desired immunization effect.