Obesity is the appearance caused by excessive accumulation of fat in the body, and is not a sign of “health” as the people say. Obesity not only affects the beauty of the body, but is also closely related to many diseases, especially the correlation with tumors, which has attracted the attention of the medical community in recent years. Does obesity have any effect on the early detection of prostate cancer? A study led by Professor Dingwei Ye of the Department of Urology at the Cancer Hospital of Fudan University, with Drs. Yao Zhu and Chengtao Han as co-first authors, found that obesity not only affects our health, but also significantly interferes with the accuracy of prostate cancer indicators commonly used in our physical examinations. The research paper was recently published in the internationally recognized journal Scientific Reports. The incidence of prostate cancer in China has been increasing rapidly over the past decade. In Shanghai in particular, prostate cancer is rapidly increasing at an annual rate of 8% and now ranks as the fifth most common malignancy in Shanghai men. At the same time, the weight of middle-aged and older men is showing a similar rapid increase. In just seven years, the incidence of obesity among adult men in Shanghai increased from 31.5% (1998-2001) to 39.1% (2007-2008), and the more dangerous abdominal obesity (also known as “beer belly”) has increased from 19.5% to 27.3%. . In the face of obese middle-aged and elderly men, it is a challenging problem to detect prostate cancer earlier and more accurately. The prostate cancer research team of the Department of Urology, Cancer Hospital of Fudan University selected people who underwent prostate puncture biopsy at two medical centers in Shanghai and Hong Kong, and measured serum prostate-specific antigen (PSA)-related tumor markers such as total PSA, free PSA percentage, p2PSA, p2PS percentage and prostate health index (PHI) to analyze whether the performance of these blood markers on prostate cancer detection is affected by obesity. Whether detection performance is affected by obesity. It was found that in obese men, the predictive accuracy of conventional cancer indicators such as total PSA and free PSA percentage for prostate cancer decreased significantly, for example, total PSA was 67.5% accurate in normal weight men, but only 52.7% in the obese group. However, the emerging index prostate health index (PHI) is less affected by obesity. In both normal-weight and obese men, the PHI was able to predict prostate cancer with a predictive validity of about 75%, significantly better than total PSA and other derived indicators. This study reaffirms that PSA has many limitations in the early detection of prostate cancer and is easily confounded by the degree of obesity. In this case, the Prostate Health Index (PHI) is more clinically valuable for early detection of prostate cancer, and we look forward to follow up to bring more experience in the application of PHI in Chinese men.