Pancreatic sarcomas are soft tissue malignant tumors that grow in various parts of the pancreas, while pancreatic cancers are a group of malignant tumors that originate mainly from the epithelium of the pancreatic ducts and follicular cells. It can be seen that pancreatic sarcoma and pancreatic cancer originate from different tissues, so pancreatic sarcoma is a malignant tumor but not a cancer, and is most common in adolescents and infants. In the early stage of pancreatic sarcoma patients, due to the small size of the tumor, most of the patients may not have any symptom, which is difficult to be detected, and it is only found when they do a comprehensive physical examination of the pancreas. As the cancer gradually increases in size, patients may experience vague abdominal pain, mostly in the upper abdomen. In addition, nausea, vomiting as well as low-grade fever and weight loss may occur. In the case of a tumor in the head of the pancreas, obstructive jaundice may also occur. Surgery, such as duodenectomy, is the preferred treatment after diagnosis of pancreatic sarcoma, and there are no targeted chemotherapy or other drugs available.