It is not recommended to take progesterone after drinking alcohol because progesterone is an acidic drug and taking progesterone after drinking alcohol will lead to an increase in stomach acid. Drinking alcohol will cause acid reflux, heartburn, especially for patients with previous gastric disease, chronic gastric ulcer, chronic gastric atrophy or bile reflux gastritis, drinking alcohol and then taking progesterone is particularly likely to lead to nausea, vomiting and other gastric mucosal erosion and irritation of the symptoms, the more serious will also be the upper gastrointestinal tract hemorrhage of the adverse reaction. After drinking alcohol, ethanol and acetaldehyde in alcohol will react with the active ingredients of progesterone, and taking progesterone after drinking alcohol will cause secondary failure of the drug and other reactions. In addition, some substances in progesterone can also cause allergic reactions, which can lead to itching of the skin, body discomfort and other conditions, so it is not recommended to take progesterone after drinking alcohol.