Blood creatinine 580μmol/L is mostly caused by pathologic factors, which may be seen in acute and chronic renal failure and other diseases, clinically, we should first find the cause of creatinine elevation, and the treatment includes dialysis treatment and non-dialysis treatment. 1. Acute renal failure: including pre-renal, renal and post-renal. Pre-renal renal failure should pay attention to timely correction of systemic circulatory hemodynamic disorders, including rehydration, plasma and albumin infusion, infection control. Post-renal should be promptly relieved of obstruction to maintain the patency of urine. If the conservative treatment is ineffective and reaches the dialysis indication, dialysis treatment should be carried out as early as possible. 2. Chronic renal failure: it mainly includes treatment of primary disease, treatment of complications (renal anemia, renal bone disease, etc.), prevention and treatment of infections, renal replacement therapy, etc. If creatinine is elevated due to diabetic nephropathy or hypertensive renal damage, it should be actively treated by lowering sugar and blood pressure. In addition, renal replacement therapy includes hemodialysis, peritoneal dialysis and kidney transplantation. Blood creatinine 580μmol should be combined with specific conditions to give different treatment programs, it is recommended to seek medical treatment in a timely manner and strictly follow the physician’s instructions for medication to avoid aggravating the condition.