Due to the physiological and anatomical changes of pregnant women, its clinical manifestations are often atypical, which often leads to misdiagnosis, misdiagnosis and even delayed treatment, endangering the safety of pregnant women and fetal life. According to domestic medical data, the mortality rate of pregnant women with appendicitis is as high as 2% and the fetal mortality rate is as high as 20%. The pathological characteristics of acute appendicitis during pregnancy: First, the inflammation of pregnant women with appendicitis can spread easily, and the toxins produced by the bacteria can affect the fetus through the blood, causing fetal hypoxia and, in severe cases, fetal death; the inflamed appendix can also directly stimulate the uterus, causing uterine contractions, resulting in premature delivery or miscarriage. During pregnancy, the pelvic organs of pregnant women are congested and the inflammation of appendix develops rapidly, so the rate of appendiceal perforation and necrosis is higher. As the number of months of pregnancy increases, the distended uterus can compress the cecum, appendix and ascending colon, making their blood flow impaired, peristalsis weakened, and feces can easily accumulate; once the appendix is obstructed, it is not easy to relieve itself. In late pregnancy, the distended uterus pushes the omentum to one side, blocking the movement of the omentum and preventing it from wrapping the inflamed appendix, which often results in severe diffuse peritonitis after perforation. Fifth, appendicitis occurs in late pregnancy, due to the abdominal bulge, resulting in abdominal pressure points are not obvious, abdominal muscle tension is not typical, easy to be misdiagnosed. After delivery or premature birth, the uterine contraction can cause the inflammation that has been restricted to spread rapidly. What should I do if a pregnant woman has appendicitis? Considering the effect of medication on the fetus, mothers who love their children are often prone to take the countermeasure of tolerating and carrying the disease, while some patients are afraid of surgery and want to use non-surgical treatment methods, without realizing that these are very harmful. First of all, conservative treatment with medications is not recommended for pregnant women because during pregnancy, medications can enter the fetus through the placenta and some of them can affect the development of the fetal organs and cause malformations, while others can promote uterine contractions and cause premature delivery or miscarriage. In addition, the prognosis of appendicitis in pregnancy is directly related to the stage of pregnancy and the degree of appendiceal lesion at the time of surgery. Early diagnosis and surgery is the safest treatment for patients. If the patient tolerates it, the inflammation will be delayed, resulting in septic perforation of the appendix and even diffuse peritonitis, which will increase the difficulty of surgery and the risk of surgery for the pregnant woman, resulting in increased mortality of the pregnant woman and the fetus. Therefore, once a pregnant woman suffers from appendicitis, early surgery should be the best policy.