7 items that need to be reviewed regularly for hepatitis B patients Many patients with slow hepatitis B do not pay much attention to their disease and do not review it regularly, always thinking that the disease is not developing that quickly or that there is no problem if they have no symptoms. Some of them only check the liver function to see if it’s normal, even if they do, and don’t take the other tests their doctors recommend seriously. This is actually a misconception. Some patients do not even know the difference between liver function and quantitative hepatitis B DNA testing, thinking that a liver function check will tell them the amount of virus or the presence of cirrhosis. Therefore, it is necessary to let patients with chronic hepatitis B understand the significance and role of related tests. 1, liver function Liver function includes a number of indicators such as glutamate aminotransferase, glutathione aminotransferase, glutamyl transpeptidase, alkaline phosphatase, cholinesterase, albumin, prealbumin, total bilirubin, total bile acids and so on. Among them, glutamyl transaminase and glutamic oxalacetic transaminase reflect the severity of hepatocyte necrosis and liver parenchymal damage. Total bilirubin, glutamyl transpeptidase and alkaline phosphatase reflect the metabolism of the liver and biliary stasis. Albumin, prealbumin, and cholinesterase reflect the synthetic function of the liver. Sometimes normal aminotransferases do not mean normal transpeptidases, etc. Therefore, we still recommend patients with slow hepatitis B to check big liver function instead of small liver function. 2, HBV-DNA Hepatitis B DNA quantitative test directly reflects the state of hepatitis B virus replication and the strength of infectiousness, which can be used to observe the effect of antiviral treatment and guide the selection of antiviral drugs. Some patients expressed confusion about the difference between the five hepatitis B items and HBV-DNA, in fact, the five hepatitis B items reflect the presence of the virus or antibodies, and do not reflect the amount of virus. 3, color ultrasound examination Color ultrasound examination visually reflects the morphological changes of the liver, showing the size of the liver, whether there is damage, sclerosis or portal hypertension, whether there are stones, cysts or occupancies. The morphological changes of the liver can be effectively monitored. 4.Liver elastometry Liver elastometry assesses the degree of liver fibrosis by measuring liver stiffness with a transient elastography technique. This test is a non-invasive, painless, rapid, simple and objective quantitative detection of liver fibrosis. Liver elastography uses ultrasound technology to assess the hardness of the liver through the elasticity values reflected from the liver tissue to low-frequency ultrasound vibration waves; the greater the elasticity value, the harder the texture of the liver tissue and the more severe the degree of fibrosis. Liver fibrosis is a dynamic process of injury and repair, and the progression of liver fibrosis cannot be detected by a single liver aspiration. Compared with multiple liver punctures to detect the development of liver fibrosis, liver elastometry is undoubtedly more advantageous with its non-invasive and convenient nature. The liver is an important site for the synthesis of various coagulation factors and the synthesis of fibrinolytic enzymes. When liver disease occurs, the reduction or depletion of coagulation factor synthesis and the production or increase of anticoagulant substances often cause abnormal changes in the coagulation mechanism. As a result, there will be some patients who often have mild bleeding when brushing their teeth, or have difficulty stopping bleeding when it occurs due to trauma. The four coagulation items effectively respond to the normal or not of the coagulation mechanism, and to a certain extent reflect the progress of liver disease. 6, blood routine There are many patients with slow hepatitis B do not understand what the blood routine can find out, thinking that the review of the blood routine is completely redundant, without any meaning. This idea is incorrect. The actual fact is that the actual blood is a basic test, for patients with slow hepatitis B, because the liver has a certain function of hematopoiesis, blood storage and regulation of circulating blood, so it can reflect the liver’s hematopoiesis and blood circulation, and also indicate whether there is hypersplenism, whether there is a concurrent bacterial infection, and can even find many early signs of systemic disease. For patients with chronic hepatitis B treated with interferon, regular blood tests are even more important because interferon can suppress bone marrow images and reduce white blood cells. It is through the review of blood routine that further guidance can be given to interferon therapy. 7.A-fetoprotein A-fetoprotein is generally used as a diagnostic index of primary liver cancer, and it has important value for judging the condition and prognosis of liver cancer. Therefore, for patients with chronic hepatitis B with a history of more than ten years, especially for men over 40 years old, the examination of alpha-fetoprotein is very important. It is important to try to achieve early detection and early treatment so as not to miss the best time. The above tests can be reviewed generally once every six months to a year. Only with regular review can we monitor the development of the disease throughout the whole process as much as possible in order to get the best timing and treatment effect.