Clofazimine side effects are mainly skin and mucous membrane coloration, some patients may also appear body fluid coloration and gastrointestinal reactions, individual patients may appear dizziness, drowsiness and other discomforts. 1. Skin and mucous membrane staining: mostly appear after 2 weeks of medication, manifested as skin and mucous membrane red staining, the degree of staining is generally proportional to the dose, the course of treatment, can be pink, brown or black, generally stopping the drug for 2 months after the pigmentation can be gradually reduced, to 1 ~ 2 years can be completely faded. 2. Coloration of body fluids: such as sweat, milk, urine, semen, saliva, etc. show light red. 3. Gastrointestinal reactions: such as nausea, vomiting, loss of appetite, abdominal pain, diarrhea and so on. 4. Others: such as dizziness, somnolence, upper gastrointestinal bleeding, skin itching, hepatitis, skin hypopigmentation, Asperger’s syndrome, acute abdomen. Clofazimine is commonly used in soft gelatin capsules and gelatin pills, and is the drug of choice for the treatment of verrucous leprosy. It can also be used for the treatment of erythema nodosum leprosum reaction and acute leprosy reaction caused by other drugs, or used in combination with ethylthioisonicotinamide or rifampicin for the treatment of infections caused by sulfone-resistant strains of bacteria. It should be noted that the use of any preparation of Clofazimine is contraindicated in people who are allergic to the product, in people with severe hepatic or renal dysfunction, in people with severe gastrointestinal disorders, and it is recommended that the drug be taken with food or milk. Patients should use this drug in accordance with the doctor’s instructions, and if the above discomfort occurs during the use of the drug, and the symptoms are more serious or continue unrelieved, they should consult a doctor in time.