Typical angina pectoris is not difficult to recognize. However, studies have shown that only 60% of angina pectoris caused by ischemia is typical angina pectoris, and almost all the rest are atypical chest pain. The clinical symptoms of atypical angina are diverse, which can easily lead to misdiagnosis or omission, and even delay the timing of treatment. Atypical angina can be manifested only by palpitations, discomfort in the precordial region, pressure or boredom, or pain in the radiating area only. Some patients complain of tightness or pain in the throat, jaw pain, toothache, neck pain, scapular pain, fingertip pain, abdominal pain, and radiating pain in the upper arm. Elderly people often have atypical symptoms and may only feel chest tightness, shortness of breath and fatigue. Older diabetic patients even feel only chest tightness without any obvious chest pain site. It is not advisable to easily exclude angina pectoris (especially if the location is atypical). Angina can radiate to almost any part of the body except the lower extremities. If a patient presents with toothache immediately after activity, even if other features are atypical, angina should be highly suspected and further investigated. In men, over 40 years of age, smokers, obese, with diabetes, hypertension, hyperlipidemia and other factors, angina due to coronary artery disease should be actively excluded even if the symptoms are atypical. Elderly people and diabetic patients with atypical symptoms are more common. For example, some elderly patients with angina attack may show shortness of breath after activity and may have no symptoms such as chest tightness and chest pain at all, which can be easily mistaken for cardiac insufficiency. Atypical symptoms in angina are not always immediately judged correctly even by professionals. Most patients often need to undergo some special tests (such as exercise test, nuclear, dynamic ECG, coronary CTA, etc.) to further clarify the diagnosis. Patients with atypical symptoms are recommended to seek professional consultation at a regular hospital as soon as possible to avoid delaying the diagnosis and treatment, which may lead to irreversible consequences.