Azoospermia, one of the major causes of male infertility, is very harmful. Some men say that azoospermia does not just make men unable to have children. In fact, the harm of azoospermia is much more than that, for male friends, sometimes azoospermia brings other harm, more terrible than infertility: azoospermia patients are most obviously caused by changes in male hormone levels, the most important when it comes to testosterone that is androgenic changes! Testosterone plays a vital role in a man’s life: 1. The effect of testosterone on infants: In the first week after the birth of a young male infant, the concentration of testosterone begins to rise and is maintained for several months at a concentration commensurate with puberty. Testosterone has an important role in the formation of the male penis and scrotum. 2, the impact of testosterone on adolescent males: testosterone is a kind of androgen, male sexual behavior and androgen-related. When the testicles begin to secrete androgens during puberty, male sexual behavior begins to sprout and enhance. It produces adult body odor; skin and hair become more oily, acne; pubic hair and armpit hair; growth increases dramatically, accelerating bone growth; penis grows; libido and erection increase; voice becomes low; facial subcutaneous fat decreases; throat nucleus grows; muscle strength and quality increase, etc. 3, the impact of testosterone on adult men: testosterone on adult men have four main effects: maintain muscle strength and quality; maintain bone density and strength; maintain libido and erection times; refresh and enhance physical performance. What are the risks of low testosterone for men? The main hormones related to male reproductive function are gonadotropin-releasing hormone (LH) secreted by the hypothalamus, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and testosterone (TES) secreted by the anterior pituitary gland. They are the “Big Five” of fertility, working in close collaboration with each other. For example, FSH can “order” the epithelial cells of the varicocele to promote the development and maturation of sperm; LH is an enabler that stimulates the secretion and synthesis of testosterone in the testicular mesenchyme. Testosterone has direct or indirect physiological effects on all systems of the body. Testosterone deficiency will lead to a series of pathophysiological changes in bones, muscles, fat, blood, cardiovascular and other tissues and organs, as well as emotional and cognitive functions, and sexual function. 1, testosterone is too low, seriously affect the quality of male sperm, resulting in a decrease in the number of sperm, the formation of oligospermia, in serious cases can lead to azoospermia; resulting in a decrease in sperm motility, the formation of weak sperm, and less sperm, azoosperm, weak sperm will affect male fertility, leading to infertility, so if testosterone is low men should go to the hospital for treatment in a timely manner! 2, the impact of testosterone on bones: recent studies abroad and in our department have shown that patients with androgen deficiency are more likely to have reduced bone mass and osteoporosis. The reason for this is the decrease in testosterone, accompanied by a decrease in biologically effective testosterone and an increase in sex hormone binding globulin can increase the rate of bone density loss by more than three times. 3, the impact of testosterone on muscle tissue: the reduction of serum free testosterone can make men have less progressive muscle mass, reduced muscle strength, easy fatigue and reduced ability to perform daily activities; 4, the impact of testosterone on fat: the reduction of testosterone levels can lead to an increase in visceral fat and weight gain, mainly abdominal obesity; 5, the impact of testosterone on mood and cognition: bioactive testosterone levels have an important regulatory role on mood and cognition. If the endogenous testosterone is too low, it can lead to anxiety, insomnia, memory loss, thinking response and intellectual impairment in men. 6, testosterone on sexual function: testosterone can regulate libido and erectile function through the central and local tissues, and plays a decisive role in male libido. Testosterone can directly stimulate bone marrow stem cells and synthesize erythropoietin through the kidneys to increase the number of red blood cells and hemoglobin level, and testosterone deficiency can lead to anemia. Therefore, all patients, based on the principle of prevention before illness, should follow up for a long time, at least once every six months or once a year to review the “five sex hormones”, if there are abnormalities in time to seek medical advice is the best policy! You should also pay attention to the weight change, abdominal circumference and hip circumference ratio, which can simply provide your basic health status.