The perimenopause includes the menopausal transition (i.e., from the onset of endocrinological, biological, and clinical features of near-menopause) and the first year after menopause. The age of menopause for women is around fifty years. For the sake of women’s health, family well-being and social harmony, it is important to pay attention to women in their 40s and 50s who are in the perimenopausal phase. Perimenopause is a normal physiological change, most women do not have any discomfort, but some people have some discomfort. The main manifestations are: 1. Menstrual changes: Most women start menstrual changes around the age of 40, with an average age of menopause of 49.5 years. A small number of women develop functional uterine bleeding, which even causes severe anemia. 2. Genitourinary tract changes: The genital organs start to atrophy, the mucous membrane becomes thinner, prone to senile vaginitis and painful intercourse, unable to hold urine, etc. 3. Neuropsychiatric symptoms: mainly flushing, bouts of fever, sweating and other vasodilatory symptoms. Emotional instability, agitation and irritability, depression and irritability, memory loss, and reduced work ability. 4. Skin wrinkles gradually increase, some itching, hair starts to turn white and fall off. Increased fat in the abdomen and hips, easy to gain weight. 5, changes in the cardiovascular system: blood pressure is prone to fluctuations, often hypertension, anterior heart area stuffiness and discomfort, palpitations, shortness of breath, increased incidence of atherosclerosis, and increased incidence of coronary heart disease. 6, osteoporosis: from about 40 years old, women’s bones begin to decalcify, losing 1% of calcium each year, if not supplemented with calcium, can lead to osteoporosis. The consequences are compression of the spine, short stature, posterior spinal protrusion and walking difficulties, and in severe cases produce compression fractures of the spine, prone to fractures, commonly in the distal radius of the upper limb and the femur of the lower limb. The incidence of fracture in women is 6 to 10 times higher than that in men. How to solve these problems? One is perimenopausal health care, and the other is perimenopausal hormone therapy. For perimenopausal health care, first of all, you should learn to regulate your emotions and have a good mood, learn to make friends and cultivate your hobbies at this time. This time also learn to groom themselves, dress themselves, all ages have the charm of each age group. This will increase your self-confidence. It’s also a good way to stay youthful by spending time with young people. It is also important to be good at organizing your life, to have work and leisure, and to exercise properly. This is the age of many things, but also regular physical examination. Next, we should pay attention to diet, drink more milk to supplement calcium, and eat more fruits and vegetables. Another hot question: Do I need hormone therapy during perimenopause? Yes. Because women’s hormones are low or unstable, a number of symptoms and problems occur during this period, including menstrual disorders and menopausal syndrome. Hormone therapy during the perimenopausal period can be effective in improving these symptoms and can improve a woman’s quality of life. Studies have also shown that hormone therapy during this time can prevent a number of menopause-related diseases, including osteoporosis and pelvic floor muscle relaxation, in addition to menopausal symptoms, which can be treated with hormone supplementation. But are there any risks? There are risks associated with hormone therapy for menopausal women, and the risks and benefits need to be weighed against each other. Some of the more recognized benefits of hormone supplementation include: improvement of menopausal symptoms, improvement of genitourinary tract atrophy, osteoporosis, and in some studies, prevention of Alzheimer’s disease. In terms of risks, there is a risk of stroke, as well as thromboembolism and breast cancer, but it is not significant. But what about minimizing the risk in order to use it safely? We should understand that not all women need to use it. Although I say they do, not 100% of women need to use it. It must be used scientifically and reasonably to be safe. The goals of hormone therapy for perimenopausal women: 1. short-term treatment goals: improve menopausal symptoms (hot flashes, irritability, loss of libido, insomnia, dull skin); improve the function of the genitourinary tract; improve irregular vaginal bleeding and improve quality of life. 2. long-term treatment goals: prevent osteoporosis in women and reduce the incidence of fractures; prevent the occurrence of dyslipidemia and cardiovascular and cerebrovascular related diseases; improve quality of life and Reduce family and social burden. Confusion and misconceptions about perimenopausal hormone therapy. One is abuse and the other is fear of use. The most important characteristic of women in this age group is the psychological barrier of fear of aging, their menstruation is gone, they have disorders, they are going to old age, and they are very afraid of aging. They want to have a way to keep themselves from aging. Some people suggest that I should use some hormones in advance, after the age of 40, whether this can retain youth. There are also advertisements for drugs that can slow down the aging of the ovaries and delay menopause. We should understand that not all ovaries are in decline at the age of 40, and not everyone needs hormone supplements, nor can everyone use them. Is there a way to delay ovarian aging? To tell you that there is no clear scientific method to delay or stop the declining function of the ovaries, it is not possible. We can only say that we can improve some of the problems caused by ovarian decline, but we can not stop this decline, if people are 100 years old without menopause is impossible. There are also people who think that a woman’s bad temper is menopause. We already have standards for menopause, and there are certain indicators to determine if you are experiencing problems caused by ovarian decline before it can be menopause. It is because of these misconceptions and abuses that various risks are increased. The second misconception is the fear of use. This is also very common, refusing hormones and thinking that if you use them, you will gain weight. Female hormones are hormones that are necessary to maintain the functions and organs of a woman throughout her life, and they are not what we usually call glucocorticoids that cause fat gain. Young girls have much higher female hormones than old women, but old women are fatter than girls. Some people say that if you use hormones, you can’t stop and you will become dependent. This is also a false statement. Hormones are not dependent, they are what you need, and you use them when you need them, but not when you don’t need them, or when you can’t use them. It’s not as risky as glucocorticoids when you stop. Use it when you need to use it. Others say that menopause is a natural physiological process and that the application of hormones violates natural laws. Menopause is natural, and it is a natural process for every woman. Menopause itself is not a disease, and aging is also natural. However, menopause can cause some diseases related to menopause, such as menstrual disorders and osteoporosis. In addition, aging will cause diseases related to aging, such as arthritis, hypertension, heart disease, etc. The incidence of these diseases will increase significantly in old age. The purpose of hormone therapy is not to prevent menopause, nor is the use of medication to prevent aging. But we are using these drugs to treat menopause-related diseases. So it’s not a violation of the law, but rather that we need to prevent the diseases that come with menopause or aging. At this time when hormone deficiency is again a period when diseases of old age are laid down, a comprehensive regimen and various health care measures together with medication will enable you to overcome these problems and create a harmonious life in old age.