Whether a pregnant woman has to undergo amniocentesis after having non-invasive DNA depends mainly on the results of the non-invasive DNA test. If the result suggests a low risk, generally there is no need to undergo amniocentesis, and if it suggests a high risk, amniocentesis should be performed. Non-invasive DNA is taken from the peripheral blood of the pregnant woman to extract the DNA of the fetus, and then through sequencing technology to see if the fetus has any chromosomal lesions. Generally, Down’s syndrome screening is a level 1 prenatal screening, while non-invasive DNA is a level 2 screening, which is mostly used for pregnant women who are at risk of Down’s syndrome screening or who have missed Down’s syndrome screening. Non-invasive DNA is not a substitute for amniocentesis because the fetal DNA extracted by this test is the free DNA in the pregnant woman’s blood, whereas amniocentesis extracts the fetus’ own DNA. Therefore, if a high-risk problem is detected after this test, it is still necessary to undergo a further amniocentesis to get a more accurate conclusion. In addition, amniocentesis is required if there are indications for amniocentesis, such as a family history of genetic predisposition. Once a pregnant woman finds out she is pregnant, she should undergo all the prenatal checkups on time, so that any problems can be detected and dealt with in a timely manner, which is of great help to the health of the pregnant woman herself and the fetus.