Do gallbladder stones have to be removed once they are formed? We all know that gallbladder stones can cause blockage of the bile ducts, resulting in bile accumulation in the gallbladder, poor bile excretion, and increased bile duct pressure, which induces acute cholecystitis. At this time, the patient often shows abdominal pain, abdominal distension, nausea, vomiting and discomfort, accompanied by radiating pain in the right shoulder and back. Patients who seek timely medical attention to give anti-infection, antispasmodic, rehydration support treatment can quickly relieve the patient’s symptoms and control the inflammation of the gallbladder. Therefore, for recurrent acute stone cholecystitis, patients are advised to have the gallbladder and stones removed as soon as possible to avoid serious complications such as acute cholangitis and acute pancreatitis. In principle, once gallbladder stones are found, there are indications for gallbladder and stone removal. Since 80% of gallbladder cancer patients have gallbladder stones in combination, gallbladder stones and gallbladder cancer are closely related. However, gallbladder stones are benign diseases after all, if the patient does not have recurrent attacks, it is possible to observe for a period of time. If the gallbladder stones have recurrent gallbladder inflammation, then it is recommended to remove them as soon as possible.