After taking entecavir, you should have the appropriate examination, if there is no abnormality, no treatment, if there is abnormality, then liver protection, antiviral, drug treatment, and so on. The change from a triple positive to a double positive does not have much clinical significance, but should mainly depend on the results of viral tests, liver function tests, and imaging tests. When the change from triple positive to double positive, viral test can be conducted to see if it is caused by mutated virus, if so, treatment will be given, if not, then look at the liver function test or imaging test, if these two show that there is damage to the liver, it should also be treated in time, if it shows that the liver test is normal, then it means that the disease is going in the right direction. Hepatitis B can be treated with interferon or nucleoside analogs under a doctor’s supervision, or with antiviral drugs to block the disease, or with some traditional Chinese medicines to regulate the disease.