A little pain at the end of urination is mostly caused by urinary tract infections, prostatitis, chronic cystitis, etc.: 1. Urinary tract infections: such as E. coli, Staphylococcus aureus and Aspergillus infections, these bacteria can induce congestion, edema and ulcers in the mucosa of the urethra, and the sensory nerves on the surface become more exposed and sensitive, so the performance of a little pain at the end of urination can occur. In this case, it is recommended to go to the hospital for routine urine testing. If a large number of white blood cells are found in the routine urine, it is recommended to give quinolone antibiotics for treatment; 2. Prostatitis: mainly seen in men, when there is bacterial or sterile inflammation of the prostate, resulting in swelling, the painful radiating area is sometimes in the urethra, which may cause a little pain at the end of urination. The treatment is based on alpha-blockers with Chinese medicines, which are more effective; 3. Chronic cystitis: mostly seen in young and middle-aged women, mostly in adenoidal cystitis and interstitial cystitis, dominated by painful urination and hematuria, and painful urination is mostly a little painful at the end of urination. It is recommended that cystoscopy be performed to clarify the diagnosis and treat the symptoms.