During pregnancy, women are particularly prone to wisdom tooth pericoronitis due to changes in hormonal regulation and changes in body functions, as well as poor eruption of the wisdom tooth itself. This is a very common clinical condition and relatively difficult to treat. The overall philosophy of treatment for peri-coronitis during pregnancy is to treat the wisdom teeth conservatively and locally, and to avoid the more invasive wisdom tooth extractions during pregnancy. Generally, during the acute and severe painful period of pericoronitis, we apply hydrogen peroxide and saline, with the aid of a syringe, to the blind pockets around the wisdom teeth to alternately rinse them of pus and food debris. In general, systemic medication is avoided during pregnancy, but if the inflammation is indeed severe and medication is needed, the cephalosporins available during pregnancy are usually the mainstay and no nitroimidazoles should be used.