When heart valve disease is complicated by embolism, it can cause malignant conditions such as cerebral embolism, limb artery embolism, superior mesenteric artery embolism, renal artery embolism, splenic embolism, and pulmonary artery embolism. Heart valve disease can cause atrial fibrillation, and atrial fibrillation leads to left atrial thrombus, which can cause embolization of peripheral arteries if dislodged, such as cerebral embolism, limb arterial embolism, superior mesenteric arterial embolism, renal arterial embolism, splenic embolism, and pulmonary arterial embolism. In addition, isolated atrial fibrillation can also cause left atrial thrombosis and cause peripheral artery embolism. 1. Cerebral embolism: patients with cerebral embolism will have hemiplegia and aphasia, with rapid onset and high mortality rate. 2. Arterial embolism of the extremities: patients with arterial embolism of the extremities may suffer from ischemia and necrosis of the limbs. 3. Superior mesenteric artery embolism: patients with superior mesenteric artery embolism will have necrosis of the small intestine, and severe hemorrhagic enteritis. 4. Renal artery embolism: patients with renal artery embolism may have hematuria. 5. Splenic embolism: patients with splenic embolism may have pain in the splenic region. 6. Pulmonary artery embolism: patients with pulmonary artery embolism will have shortness of breath, chest pain and hemoptysis. If the patient has any uncomfortable symptoms, he should seek medical treatment in time to find out the cause of the disease and then treat it.