Heart valve disease at the age of 65 may be related to rheumatic fever, infective endocarditis and other diseases, and may be caused by degenerative changes in the valve disease, etc. Symptomatic treatment needs to be carried out according to the relevant causes. 1. Rheumatic fever: Rheumatic fever is usually caused by group A beta-hemolytic streptococcus infection, which will cause patients to have fever, swelling and pain in the joints, etc. If left untreated, the disease will gradually affect the heart, causing patients to experience discomfort in the heartbeat, chest tightness and other symptoms, which in the long run will lead to heart valve disease in people aged 65. If the heart valve disease is caused by rheumatic fever, you can go to the hospital for heart valve replacement surgery, which can make the heart valve disease improve. 2. Infective endocarditis: Infective endocarditis is usually caused by a variety of pathogenic bacterial infections, which can be accompanied by heart failure, palpitations and other symptoms, and if not treated in time, it may gradually affect the heart valves, resulting in heart valve disease. It can be treated with vancomycin as prescribed by the doctor, and valve replacement can be performed if necessary. 3. Valve disease caused by degenerative changes: with the change of lifestyle and the acceleration of the aging process, degenerative valve disease in the elderly is increasing year by year in our country, mainly due to the degenerative changes in the calcification of the valve in the elderly. Aortic valve lesions are the most common, followed by mitral valve lesions. Heart valve disease mainly includes aortic valve, mitral valve, tricuspid valve and other valve stenosis or closure insufficiency, there is a need to promptly consult a doctor, under the guidance of the doctor to identify the cause of the disease, standardized treatment.