(1) Smoking. 80-90% of laryngeal cancer patients have a long history of smoking, and the risk of laryngeal cancer for smokers is 3-39 times higher than that for non-smokers. (2) Drinking alcohol. Long-term intake of alcohol will damage the laryngeal mucosa epithelium and affect immunoglobulin synthesis, thus resisting immune function. (3) Sex hormones. There is a significant gender difference in the incidence of laryngeal cancer, with men significantly more than women. (4) Environmental occupational factors, studies show that workers exposed to asbestos, mustard gas, copper, aluminum, etc. have higher risk of laryngeal cancer, and the incidence rate is higher in urban than remote rural areas. (5) Trace elements, whole blood test of laryngeal cancer patients found that low magnesium and high nickel is a factor in the development of laryngeal cancer. (6) Biological factors, HPV infection is the cause of laryngeal cancer, and H. pylori may also play an important role in the development of laryngeal cancer. (7) Other, ions, rays, genetic factors, mental factors, etc.