The early symptoms of prostate enlargement are frequent urination and increased nocturia, which can progress to urinary retention as the condition worsens. There are a number of medications that can induce and aggravate urinary retention with a rapid response, usually within 2 to 4 hours after the medication is administered. If a patient with prostate enlargement also has other diseases, he or she should be aware of the effects of these medications on his or her urinary system when taking them for treatment. The following are some of the drugs that should be used with caution by patients with prostate enlargement: 1. Anti-psychotic drugs Chlorpromazine, Fenazepam, Haloperidol, Clozapine, etc., can cause difficulty in urination. 2, antidepressants promethazine (mipramine), doxepin, amitriptyline, chlorpromazine, etc., can induce urinary retention. 3.Antiasthmatic drugs Aminophylline, theophylline, ephedrine, isoproterenol (Oxybutynin), etc., can cause difficulty in urination. 4.Cardiovascular drugs such as propranolol, nifedipine and verapamil can inhibit the contraction of the bladder muscle and cause urinary retention. 5. Antispasmodics Gastrointestinal painkillers such as belladonna, atropine, scopolamine, scopolamine (654-2), gastric ulcer pills, anaesthesia (Orphenonium bromide), and pramipexine (Propantaline) can cause relaxation of the bladder muscle, resulting in inability to urinate. 6, strong diuretics tachyphylaxis, diuretic acid, etc., can make the electrolytes out of balance, which in turn leads to urinary retention. Therefore, patients with prostate enlargement must switch to medium-acting diuretics, such as dihydrocoumaric acid, or low-potency diuretics, such as Antiseptic, for treatment. 7. Anti-allergic drugs Finasteride (promethazine), Halohydrin (multiply Halohydrin), Phenothiazine, Paracetamol, as well as Azatadine, Mequitazene, etc., can increase the difficulty in urination, and can be treated with Xyosmin (Astemizole) instead. 8, topical drugs Atropine eye drops and ephedrine nasal drops should also be used with caution. 9.Other drugs Androstanes, isoniazid, mecamylamine, vincristine (triclopidine) and traditional Chinese medicine huashan ginseng, heliotrope, etc. can cause urinary retention. Currently commonly used anti-cold medications such as ketamine, cold pass, cold spirit, cold clear, quick-acting cold capsule, etc., should also be used with caution because they contain paracetamol. In conclusion, patients with prostate enlargement should try to avoid or use less of the above-mentioned drugs to avoid aggravating their condition.