”Central plasma disease” is central plasma chorioretinopathy (CSC), which is one of the more common fundus diseases. The exact cause of this disease is not known, but it is generally believed to be triggered by mental stress and overexertion. Patients are mostly young men aged 20-45 years old, but women can also be seen, and most of them have monocular disease. The fundus is characterized by neuroepithelial detachment in the posterior pole, which may be accompanied by small pigment epithelial (RPE) detachment. The disease is a self-limiting disease, some patients can recover on their own in about 3 months, but it is also prone to recurrence, and multiple recurrences can lead to significant impairment of visual acuity. Clinical manifestations: 1. Central vision Sudden mild decrease in central vision of the affected eye, temporary hyperopia of 0.50D-2.50D may occur. 2. Central dark spot Patients feel that their eyesight is hazy, dark and somewhat yellowish, and there is even a disc-shaped shadow in the center of the visual field. 3. Microphthalmia and metamorphopsia The affected eye has small visual objects, straight lines become curved and distorted. Auxiliary examination: 1. Fundus examination shows a (or 2-3) superficial detachment area of neuroepithelial layer of 1-3 PD in the macula or posterior level with round shape and clear boundary. The detached area is dark, slightly elevated, and the central concave reflection disappears. 2, fundus angiography (FFA) fluorescence imaging, pigment epithelial detachment area in the pre-arterial fluorescence leakage, with the passage of time its leakage gradually enhanced, and continued until the late contrast, and when the normal choroidal fluorescence disappeared it is still clearly visible. This is due to the accumulation of fluorescein in the subepithelium with the plasma, resulting in long-lasting fluorescence. This test is long and often requires an appointment. It is contraindicated for those who are allergic to sulfonamide drugs. 3, OCT examination can be seen as an elevated neuroepithelium with fluid underneath as a liquid dark area with no reflective signal, or with dotted patches and slightly high reflective signal between them. Some patients can even see the RPE fracture point, i.e. the leakage point. This examination method is accurate, rapid and non-invasive. Treatment: 1. Laser photocoagulation Laser photocoagulation of the leaky spots is the treatment of choice for this disease. About a week after photocoagulation, the plasmacytic detachment of the neuroepithelial layer begins to subside and may disappear within 2-3 weeks. This method has certain indications: there is obvious fluorescence leakage, the leakage point is located in the central small concave 250μm or more; there is a large area of neuroepithelial layer detachment; the disease duration of more than one month, and there is a persistent plasma detachment. 2.Photodynamic therapy (PDT) persists for more than 3 months for pigment epithelial loss of compensation, and chronic CSC without clear leakage points in general can be treated with PDT, especially for patients with choroidal neovascular membrane. It can effectively close the leakage point and shorten the course of the disease. The cost of this treatment is high, and it needs to be paid by the patient. 3.Medication such as vitamin B, lutin, etc. can be tried. Adrenal corticosteroids are prohibited. Pay attention to the relief of mental tension and other systemic factors. In conclusion, the true cause of this disease is unknown, with a tendency to self-heal and recurrence. It is mostly triggered by mental tension, poor sleep, overwork, and the influence of external cold. Therefore, prevention and early intervention treatment should be given. Avoid the above-mentioned factors that trigger the disease and avoid excessive stress and strain.