Mesoplasia is a focal plasma retinal detachment that occurs in the macular region, which is commonly known as “macular osmosis”. It mostly occurs in young people, and is more common in men, with a male to female ratio of 8:1. It mostly develops in one eye, but can also be seen in both eyes. There are often triggering factors such as stress, exertion, high blood pressure, headache, etc., but there is no clear etiology. A presentation similar to mesoplasia can be seen in patients with heavy hormone application, Cushing’s syndrome, pregnant women, SLE patients, dialysis or organ transplant patients. Patients may feel blurred, distorted, and darkened vision and smaller visual objects. Ancillary examinations: FFA is often available: strong fluorescent leaking spots are seen in the early stages and fluorescent accumulation under the retina in the late stages; neuroepithelial elevation in the lesion area with fluid accumulation visible under it and small RPE elevations on OCT. Treatment and prognosis Most patients heal spontaneously within 6 weeks after onset. Medications can help recovery, such as medications to improve microcirculation and medications to help fluid accumulation absorb. Visual recovery is good, with 90% of patients recovering visual acuity above 0.6 Laser treatment can speed up the absorption of subretinal fluid, but has no significant effect on the recovery of visual acuity. Laser treatment can be considered for patients with chronic prolonged refractory disease. If the leakage point is in the center of the macula and cannot be treated by ordinary laser, half or 1/3 amount of PDT treatment (photodynamic therapy) can be considered. The recurrence rate of CSC is 30% to 50%, mostly within one year after the onset of the disease.