Hepatitis B e antibody is an antibody produced by the immune system upon exposure to the hepatitis B virus and does not usually turn negative. A positive hepatitis B e antibody needs to be analyzed in combination with other hepatitis B markers. If combined with positive hepatitis B surface antibodies and positive core antibodies, it suggests that the body has been infected with the hepatitis B virus. However, an immune response has been generated that has cleared the virus and stimulated the body to produce a specific immune response that can protect the body from hepatitis B virus infection. If the combination of positive hepatitis B surface antigen and positive hepatitis B core antibody indicates a small hepatitis B triplet, if the liver function is repeatedly abnormal and the virus is in a high replication state, antiviral treatment is required. If it is purely positive for hepatitis B e antibody, only regular rechecking is needed. If the hepatitis B virus is below the lower line of the test value, it mostly indicates no hepatitis B virus carriage. In conclusion, when the e antibody is positive, the hepatitis B virus is at a relatively low replication level, indicating that the organism is weakly infectious, but to assess the level of infectivity, the hepatitis B viral load HBV-DNA quantification is also required.