Holmium laser is a new type of laser produced by a pulsed solid laser device made of laser crystal (Cr:Tm:Ho:YAG) with yttrium aluminum garnet (YAG) as the activating medium and doped with sensitized ion chromium (Cr), energy transfer ion thulium (Tm), and activated ion holmium (Ho). It can be applied in urology, pentacology, dermatology, gynecology and other departmental surgeries. This laser surgery is non-invasive or minimally invasive and the patient’s treatment pain is very low. Holmium laser has brought the treatment of urinary stones to a new level. Holmium laser has a wavelength of 2.1 μm and is a pulsed laser, which is the latest of many surgical lasers available. The energy generated vaporizes the water between the end of the fiber and the stone, forming tiny vacuoles, and transmits the energy to the stone, which crushes it into powder form. The water absorbs a large amount of energy, reducing the damage to the surrounding tissue. At the same time, the penetration depth of holmium laser to human tissue is very shallow, only 0.2mm, so it can do minimal damage to the surrounding tissues during stone crushing, and there is almost no bleeding, which is extremely safe. Li Bijun, Department of Urology, Zhanjiang Second People’s Hospital Treatment of urinary stones has reached a new level Holmium laser lithotripsy has a strong safety and wide applicability compared with extracorporeal shock wave lithotripsy and pneumatic ballistic lithotripsy, which are commonly used today. Extracorporeal shock wave lithotripsy uses a liquid electric or electromagnetic shock wave generator to emit high energy shock waves that penetrate the body and focus on the urinary tract stones in the body, releasing energy to break up the stones and discharging the stone fragments naturally. The machine requires accurate positioning by X-ray or B-ultrasound. The application of Holmium laser has brought the treatment of urinary stones to a new level. Holmium laser wavelength μ,. Non-membranous nephrolithotripsy, such as non-pulsed carbon dioxide laser, uses thermal effect to vaporize stones, due to the temperature. Lithotripsy under direct vision, therefore, may not be completely crushed at once and is less efficient. Shock waves can also cause tissue damage when penetrating the body, such as destruction of the glomerulus and tubules and ureteral stenosis. Repeated extracorporeal shock wave lithotripsy can lead to decreased kidney function and even kidney atrophy. Pneumatic ballistic lithotripsy for middle and lower ureteral stones tends to make the stones wash back into the upper ureter or kidney, making the procedure lose its target. Moreover, it can only be performed under a rigid ureteroscope, so it can do little for upper ureteral stones and kidney stones. This is not the case with holmium laser, which is much more efficient because stones rarely run during lithotripsy and the recoil rate is very low. It can break stones directly through cystoscopy, ureteroscopy and percutaneous nephrolithoscopy without causing tissue damage. Moreover, Holmium laser fiber is bendable and can be introduced not only through rigid ureteroscope but also through soft ureteroscope for lithotripsy. Therefore, it can effectively fragment ureteral stones and kidney stones in any area. Holmium laser treatment of bladder stones is even easier, as the holmium laser fiber is introduced through the working channel of the cystoscope, and then the laser is fired, and the stones are broken and discharged through the urethra in a few seconds, which is safe and time-saving. The success rate of endocystoscopic Holmium laser lithotripsy is over 95% in a single procedure and up to 100% in the treatment of bladder stones. This procedure has no risk of perforation or bleeding and can also treat combined urinary tract tumors, ureteral polyps, and membranous nephropathy at the same time. With an average procedure time of 25 minutes and a hospital stay of less than 3 days, treatment of bladder stones can be performed on an outpatient basis. The holmium laser lithotripsy has a significantly shorter time for stone removal after lithotripsy because the particles are finer and in powder form. Holmium laser can shatter urinary tract stones of any location and composition into powder with its unique and efficient lithotripsy method. Holmium laser is a new type of weapon with high efficiency, safety, low cost, time saving and low side effects in the treatment of urinary tract stones. Holmium laser application technology in China has also made great progress in the past two years, the performance and reliability are not inferior to foreign products, and break the monopoly of foreign high prices, so that ordinary patients can really afford to use this high-tech technology. In the past five months, the minimally invasive urology center of our hospital has performed more than 60 Holmium laser surgeries, including minimally invasive treatment of kidney stones, ureteral stones, bladder stones, urinary tract stenosis, bladder tumors, and ureteral tumors, and each case has achieved satisfactory results. In one of the cases of “congenital solitary kidney with multiple stones in solitary kidney and uremia”, percutaneous nephrolithotomy was successfully completed, and the patient’s stone was completely removed at one time, which was fully recognized by the provincial experts in minimally invasive urology. The use of holmium laser, together with ultrasonic lithotripsy and ballistic lithotripsy technology, marks that our hospital has the three most advanced lithotripsy systems and technologies at home and abroad.